Laboratory of Neuropsychology SCN Banner
Link to SCN Home Link to SCN Publications Link to SCN Projects Link to LN Home
Sebastian Guderian, M.D.
Staff Scientist, Laboratory of Neuropsychology
National Institutes of Health, Bethesda, MD, USA

E-mail: guderians at

Research Experience:

My scientific interest is focused on the physiological processes that support visual recognition memory. Currently, I am investigating how cholinergic neuromodulation influences neuronal interactions in the medial temporal lobe during visual memory formation in Rhesus monkeys. In previous work in humans I used magnetoencephalography to study how theta oscillations are related to episodic memory formation and retrieval.


Photo of S. Guderian


Journal Articles

Guderian S, Brigham D, Mishkin M. Two processes support visual recognition memory in rhesus monkeys. PNAS. 2011 Nov 29;108(48):19425-30.

Guderian S, Schott BH, Richardson-Klavehn A, Düzel E. Medial temporal theta state before an event predicts episodic encoding success in humans. PNAS. 2009 Mar 31;106(13):5365-70

Guderian S, Schott BH, Richardson-Klavehn A, Düzel E. Medial temporal theta state before an event predicts episodic encoding success in humans. Submitted.

Schiltz K, Szentkuti A, Guderian S, Kaufmann J, Munte TF, Heinze HJ, Duzel E. Relationship between hippocampal structure and memory function in elderly humans. J Cogn Neurosci. 2006 Jun;18(6):990-1003.

Guderian S, Duzel E. Induced theta oscillations mediate large-scale synchrony with mediotemporal areas during recollection in humans. Hippocampus. 2005;15(7):901-12.

Wittmann BC, Schott BH, Guderian S, Frey JU, Heinze HJ, Duzel E. Reward-related FMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation. Neuron. 2005 Feb 3;45(3):459-67.

Szentkuti A, Guderian S, Schiltz K, Kaufmann J, Munte TF, Heinze HJ, Duzel E. Quantitative MR analyses of the hippocampus: unspecific metabolic changes in aging. J Neurol. 2004 Nov;251(11):1345-53.

Düzel, E., Habib, R., Guderian, S.Heinze, H. J., (2004). Four types of novelty-familiarity responses in associative recognition memory of humans. Eur J Neurosci. 19, 1408-1416.

Düzel, E., Kaufmann, J., Guderian, S., Szentkuti, A., Schott, B., Bodammer, N., Hopf, M., Kanowski, M., Tempelmann, C., Heinze, H. J., (2004). Measures of hippocampal volumes, diffusion and 1H MRS metabolic abnormalities in temporal lobe epilepsy provide partially complementary information. Eur J Neurol. 11, 195-205.

Schott, B. H., Sellner, D. B., Lauer, C. J., Habib, R., Frey, J. U., Guderian, S., Heinze, H. J.Düzel, E., (2004). Activation of midbrain structures by associative novelty and the formation of explicit memory in humans. Learn Mem. 11, 383-387.

Düzel, E., Habib, R., Rotte, M., Guderian, S., Tulving, E., Heinze, H. J., (2003). Human hippocampal and parahippocampal activity during visual associative recognition memory for spatial and non-spatial stimulus configurations. J Neurosci. 23, 9439-9444.

Book Chapters

Guderian, S. (2003). Funktionelle Neuroanatomie. In Fragen und Antworten zur Neurowissenschaft, Budde, T., Meuth, S. (editors), Huber, Bern.

Düzel, E., Neufang, M., Guderian, S. (2006). Relationship between event-related potentials and oscillatory dynamics in episodic retrieval. In Handbook of Binding and Memory. Zimmer, H., Mecklinger, A., Lindenberger, U. (editors), Oxford University Press.

Düzel, E., Guderian, S. Oscillatory and hemodynamic medial temporal responses preceding stimulus onset modulate episodic memory. In Brain imaging and Memory, Brigitte Roeder, B., Ranganath, C., Kluwe, R.H., Roesler F. (editors), Oxford University Press, in press.

Coronal Composite image
This page was last updated March 2012